Primary endometrioid carcinoma of fallopian tube. Clinicomorphologic study

Pathol Oncol Res. 1999;5(1):61-6. doi: 10.1053/paor.1999.0061.

Abstract

Twenty cases of primary Fallopian tube endometrioid carcinoma (PFTEC) are presented in the paper. This accounts for 42.5% of all histologic forms of primary Fallopian tube carcinoma (PFTC) found in our Department. The youngest patient was 38, and the oldest 68 years (mean: 56 years). Seven patients were nulliparas. Only two cases were bilateral. According to FIGO staging, 13 cases were evaluated as stage I, 4 as II, and 3 as stage III. Due to the histologic grading, 8 tumors were classified as well, 7 as moderately, and 5 as poorly differentiated. In the time of preparation of the manuscript, 12 women were still alive, 2 of them with recurrent disease. The follow-up of patients without recurrence ranged from 4 to 120 months (median: 63). Eight patients had died (survival time: from 4 to 65 months; median: 26). Metastases were found in 8 patients, especially to ovaries. In 14/20 cases of PFTEC various forms of tubal wall invasion were observed. Blood or lymphatic vessels involvement was found in 9 patients. Six of them had died and one is alive with the symptoms of disease. Immunohistochemical detection of the mutant form of p53 protein and oncogene product, c-erbB-2, was studied in 17 cases. Nine patients exhibited simultaneous p53 protein accumulation and c-erbB-2 expression. 2/9 of these patients are alive with recurrent tumors and 4/9 died. Endometrioid carcinoma of the Fallopian tube can be characterized by a tendency to superficial invasion of tubal wall and in a half of the cases by invasion of vessels. The majority of these tumors were diagnosed at an early stage tumors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Biomarkers, Tumor / analysis
  • Carcinoma, Endometrioid / epidemiology
  • Carcinoma, Endometrioid / pathology*
  • Carcinoma, Endometrioid / secondary
  • Cell Differentiation
  • Disease Progression
  • Fallopian Tube Neoplasms / epidemiology
  • Fallopian Tube Neoplasms / pathology*
  • Female
  • Follow-Up Studies
  • Genes, erbB-2
  • Genes, p53
  • Humans
  • Life Tables
  • Menopause
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Proteins / analysis
  • Neoplasm Recurrence, Local
  • Neoplasms, Multiple Primary / epidemiology
  • Neoplasms, Multiple Primary / pathology
  • Ovarian Neoplasms / secondary
  • Parity
  • Poland / epidemiology
  • Receptor, ErbB-2 / analysis
  • Survival Analysis
  • Treatment Outcome
  • Tumor Suppressor Protein p53 / analysis

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Tumor Suppressor Protein p53
  • Receptor, ErbB-2