Norpregnane glycosides from a Thai soft coral, Scleronephthya pallida

P Kittakoop; R Suttisri; C Chaichantipyuth; S Vethchagarun; K Suwanborirux

doi:10.1021/np980273w

Norpregnane glycosides from a Thai soft coral, Scleronephthya pallida

J Nat Prod. 1999 Feb;62(2):318-20. doi: 10.1021/np980273w.

Authors

P Kittakoop¹, R Suttisri, C Chaichantipyuth, S Vethchagarun, K Suwanborirux

Affiliation

¹ National Center for Genetic Engineering and Biotechnology, NSTDA, 73/1 Rama VI Road, Rajdhevee, Bangkok 10400, Thailand. prasat@biotec.or.th

PMID: 10075773
DOI: 10.1021/np980273w

Abstract

Two new norpregnane glycosides, 19-norpregna-1,3,5(10), 20-tetraen-3-O-alpha-fucopyranoside (3) and 19-norpregna-1,3,5(10), 20-tetraen-3-O-beta-arabinopyranoside (4), were isolated from the soft coral Scleronephthya pallida, along with two known steroids, pregna-1,20-dien-3-one (1) and 19-norpregna-1,3,5(10), 20-tetraen-3-ol (2). 19-Norpregna-1,3,5(10), 20-tetraen-3-O-alpha-fucopyranoside (3) exhibits moderate antimalarial and cytotoxic activities. The chemical structures of 1-4 were elucidated from spectroscopic data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification*
Antimalarials / pharmacology
Carbohydrate Sequence
Cnidaria / chemistry*
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Norpregnanes / chemistry
Norpregnanes / isolation & purification*
Norpregnanes / pharmacology
Plasmodium falciparum / drug effects
Spectrum Analysis

Substances

19-norpregna-1,3,5(10),20-tetraen-3-O-arabinopyranoside
19-norpregna-1,3,5(10),20-tetraen-3-O-fucopyranoside
Antimalarials
Glycosides
Norpregnanes