Twelve patients with acute myocardial infarction (AMI) underwent percutaneous transluminal coronary angioplasty (PTCA). The reperfusion blood flow of the infarct-related arteries (IRA) in eleven patients was TIMI Grade 3 with residual stenosis of 15.5 +/- 8.8%. Vascular endothelial dissection complicated by angioplasty was observed in one case and the patient died after emergency coronary artery bypass graft. It is suggested that early primary PTCA in AMI may create stable and effective revascularization which will favor reducing infarct size, improving myocardial pump function, and lowering restenosis and mortality rate.