Abstract
Malaria infection of the host cells requires host-parasite recognition events mediated by adhesion and signaling molecules. Recent development of systems for stable transformation and targeted integration of exogenous DNA in malaria parasites provides a powerful tool to study the structure and function of Plasmodium attachment motifs, and their role in infection and disease.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Cell Adhesion
-
Cell Adhesion Molecules / genetics
-
Cell Adhesion Molecules / metabolism*
-
Erythrocytes / parasitology
-
Liver / parasitology
-
Malaria / parasitology*
-
Molecular Sequence Data
-
Plasmodium / genetics
-
Plasmodium / pathogenicity*
-
Protozoan Proteins / genetics
-
Protozoan Proteins / metabolism*
Substances
-
Cell Adhesion Molecules
-
Protozoan Proteins