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Promiscuous G-protein activation by the calcium-sensing receptor.
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR. Zuo H, et al. Among authors: lin x. Nature. 2024 May;629(8011):481-488. doi: 10.1038/s41586-024-07331-1. Epub 2024 Apr 17. Nature. 2024. PMID: 38632411
Structure of human GABAB receptor in an inactive state.
Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR. Park J, et al. Among authors: lin x. Nature. 2020 Aug;584(7820):304-309. doi: 10.1038/s41586-020-2452-0. Epub 2020 Jun 24. Nature. 2020. PMID: 32581365 Free PMC article.
Author Correction: Structure of human GABAB receptor in an inactive state.
Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR. Park J, et al. Among authors: lin x. Nature. 2020 Jul;583(7818):E29. doi: 10.1038/s41586-020-2543-y. Nature. 2020. PMID: 32665714 Free PMC article.
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ. Niswender CM, et al. Among authors: lin x. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. doi: 10.1021/acschemneuro.6b00036. Epub 2016 Aug 5. ACS Chem Neurosci. 2016. PMID: 27441572 Free PMC article.
Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity.
Fulton MG, Loch MT, Rodriguez AL, Lin X, Javitch JA, Conn PJ, Niswender CM, Lindsley CW. Fulton MG, et al. Among authors: lin x. Bioorg Med Chem Lett. 2020 Jul 1;30(13):127212. doi: 10.1016/j.bmcl.2020.127212. Epub 2020 Apr 25. Bioorg Med Chem Lett. 2020. PMID: 32371100 Free PMC article.
In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB.
DeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I. DeLorenzo C, et al. Among authors: lin x. J Cereb Blood Flow Metab. 2017 Aug;37(8):2716-2727. doi: 10.1177/0271678X16673646. Epub 2016 Jan 1. J Cereb Blood Flow Metab. 2017. PMID: 27742888 Free PMC article.
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.
Abdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Abdallah CG, et al. Among authors: lin x. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Jul;2(5):449-456. doi: 10.1016/j.bpsc.2017.03.019. Epub 2017 Apr 6. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017. PMID: 28993818 Free PMC article.
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