Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection

Bo Gao; Liheng He; Yujie Bao; Yingying Chen; Guanzhu Lu; Yu Zhang; Yingjie Xu; Bing Su; Jie Xu; Ying Wang; Leng-Siew Yeap

doi:10.1038/s41422-023-00781-8

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection

Cell Res. 2023 Mar;33(3):258-261. doi: 10.1038/s41422-023-00781-8. Epub 2023 Jan 25.

Authors

Bo Gao^#^{1

2}, Liheng He^#¹, Yujie Bao^#³, Yingying Chen^#^{1

4

5}, Guanzhu Lu³, Yu Zhang⁶, Yingjie Xu⁶, Bing Su^{1

2

7}, Jie Xu⁸, Ying Wang^{9

10

11

12}, Leng-Siew Yeap^{13

14}

Affiliations

¹ Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Department of Infectious Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases (20dz2261100), Shanghai, China.
⁵ Key Laboratory of Parasite and Vector Biology, Ministry of Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶ Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁷ Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁸ Department of Infectious Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xujie@shsmu.edu.cn.
⁹ Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ywangssmu@shsmu.edu.cn.
¹⁰ Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases (20dz2261100), Shanghai, China. ywangssmu@shsmu.edu.cn.
¹¹ Key Laboratory of Parasite and Vector Biology, Ministry of Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ywangssmu@shsmu.edu.cn.
¹² Shanghai Institute of Virology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ywangssmu@shsmu.edu.cn.
¹³ Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yeaplengsiew@shsmu.edu.cn.
¹⁴ Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yeaplengsiew@shsmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
Breakthrough Infections
COVID-19 Vaccines*
COVID-19*
Humans
SARS-CoV-2
Vaccination

Substances

COVID-19 Vaccines
Antibodies, Neutralizing
Antibodies, Viral

Supplementary concepts

SARS-CoV-2 variants